May 03, 2014 01:19 PM EDT By Jaleesa Baulkman, UniversityHerald Reporter

Smoking during pregnancy may raise the risk for congenital heart defects in babies, according to a recent study.

Cigarette smoking during pregnancy has been linked to many birth defects, such as cleft lips and palates, and missing and deformed limbs. Previous studies have also suggested maternal smoking may be associated with heart defects.

"I care for kids with complex congenital heart disease on a daily basis, and I see these kids and their families enduring long hospitalizations and often sustaining serious long-term complications as a result of their disease. Usually, the cause of a heart defect is unknown. I saw this research as an opportunity to study what might be a preventable cause of congenital heart defects," Patrick M. Sullivan, leader of the study and clinical fellow in pediatric cardiology at Seattle Children's Hospital, said in a statement.

For the study, researchers used birth certificate data and hospital discharge records from Washington state to determine if maternal smoking during the first trimester of pregnancy is linked to heart defects and if so, what type of defects.

They identified more than 14,000 children born with a variety of heart defects from 1989-2011. They matched these cases to 62,274 children without heart defects born in the same year. Then, researchers compared the proportion of children with heart defects whose mothers reported smoking during pregnancy to the proportion of children without heart defects whose mothers smoked. Mothers' smoking status, as well as how much they smoked daily, was available from birth certificates.

Based on their findings, newborns whose mothers smoked were at about a 50 to 70 percent greater risk for anomalies of the valve and vessels that carry blood to the lungs (pulmonary valve and pulmonary arteries) and about a 20 percent greater risk for holes in the wall separating the two collecting chambers of the heart (atrial septal defects). All of these defects often require invasive procedures to correct.

Researchers also found that in recent years about 10 percent of women giving birth reported smoking during pregnancy.

They estimated that maternal smoking during the first trimester may account for 1 to 2 percent of all heart defects.

"Women, particularly younger women, are still smoking while pregnant, despite largely successful public health efforts to reduce smoking in the general public over the past few decades," Dr. Sullivan concluded. "Ongoing cigarette use during pregnancy is a serious problem that increases the risk of many adverse outcomes in newborns. Our research provides strong support for the hypothesis that smoking while pregnant increases the risk of specific heart defects."

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